Delayed hypersensitivity drug reactions diagnosed by patch testing

Patch Testing in Adverse Drug Reactions

A CADR is a skin eruption induced by drugs, systemic or topical drugs, used in adequate doses and in the correct indications. CADRs are a frequent problem in Dermatology, but their incidence is not exactly known; 1–5% of inpatients experience such a reaction and it is a frequent cause of consultation in Dermatology [1–5]. Most CADRs are mild, but about 20% can be severe and require hospitalizat...

The role of patch testing in non-immediate drug hypersensitivity reactions

Methods Herein we present case series of various non-immediate DHRs (occurring at any time as from 1 hour after the initial drug administration) amongst which drug-related intertriginous and flexural exanthema (Baboon syndrome), DRESS syndrome, fixed drug eruption and contact dermatitis. In all cases we performed patch testing with standardized and allergens prepared at our laboratory with the ...

Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS).

BACKGROUND In some patterns of cutaneous adverse drug reactions, and depending on the culprit drug, patch testing has been helpful in confirming its cause. Its value in Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) has not been established in a large cohort of patients. OBJECTIVE The aim of the present study is to evaluate the safety and usefulness of patch testing in DRESS. PAT...

Cell Reactions in Delayed Hypersensitivity

Delayed hypersensitivity reactions to corticosteroids.

BACKGROUND Corticosteroids (CS) are widely used in the treatment of asthma, allergic disorders and other immunological diseases due to their anti-inflammatory and immunosuppressive properties. Physicians seldom suspect them of causing allergic reactions. However, more and more cases of hypersensitivity reactions to CS have been described. Reports of delayed allergic reactions to CS in patients ...